The Association between Bone Age Advancement and Insulin Resistance in Prepubertal Obese Children

H. S. Lee; Y. S. Shim; H. R. Jeong; E. B. Kwon; J. S. Hwang

doi:10.1055/s-0035-1559795

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2015; 123(10): 604-607
DOI: 10.1055/s-0035-1559795

Article

The Association between Bone Age Advancement and Insulin Resistance in Prepubertal Obese Children

Authors

H. S. Lee

¹Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, Korea
Y. S. Shim

²Department of Pediatrics, Hallym University School of Medicine, Dongtan Sacred Heart Hospital, Dongtan, Korea
H. R. Jeong

¹Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, Korea
E. B. Kwon

¹Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, Korea
J. S. Hwang

¹Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, Korea

Abstract

Objective: Obesity is associated with bone age (BA) advancement, but the underlying mechanisms remain unclear. The objective of this study was to investigate the association between BA maturation and insulin levels in obese children.

Methods: In this cross-sectional study of 93 prepubertal obese children, anthropometric data and hormonal values were measured. Subjects were divided into 2 groups based on the difference between BA and chronological age (CA) (noted as BA-CA).

Results: The study population included 39 (41.9%) males and 54 (58.1%) females with a mean age of 7.4±1.5 years. The advanced bone age group defined as BA-CA>1 year (n=44) had significantly higher HOMA-IR and fasting insulin levels, and lower quantitative insulin sensitivity check index (QUICKI). BA-CA was significantly correlated with fasting insulin (r=0.255, P=0.014), HOMA-IR (r=0.230, P=0.027), and QUICKI (r=− 0.301, P=0.003). Also, height SDS was significantly associated with ΔBA-CA (r=0.417, P<0.001). In the multiple regression analysis, HOMA-IR was identified as a significant independent predictor of BA-CA.

Conclusion: Bone age is more advanced in obese children with hyperinsulinemia and insulin resistance. These findings suggest that insulin may affect skeletal maturation.

Key words

insulin resistance - obesity - bone age

Full Text

References

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